{"id":30270,"date":"2022-09-12T16:06:38","date_gmt":"2022-09-12T11:06:38","guid":{"rendered":"https:\/\/pr.asianetpakistan.com\/?p=97898"},"modified":"2022-09-12T16:06:38","modified_gmt":"2022-09-12T11:06:38","slug":"algernon-pharmaceuticals-receives-approval-for-groundbreaking-phase-1-dmt-human-stroke-study","status":"publish","type":"post","link":"https:\/\/myanmarnewsgazette.com\/algernon-pharmaceuticals-receives-approval-for-groundbreaking-phase-1-dmt-human-stroke-study\/","title":{"rendered":"Algernon Pharmaceuticals Receives Approval for Groundbreaking Phase 1 DMT Human Stroke Study"},"content":{"rendered":"
\n

VANCOUVER, British Columbia, Sept. 12, 2022 (GLOBE NEWSWIRE) — Algernon Pharmaceuticals Inc.\u00a0(the \u201cCompany\u201d or \u201cAlgernon\u201d) (CSE: AGN) (FRANKFURT: AGW0) (OTCQB: AGNPF) a clinical stage pharmaceutical development company is pleased to announce that it has received approval to conduct a Phase 1 clinical study of an intravenous formulation (“IVF”) of AP-188 (\u201cN,N-dimethyl tryptamine\u201d or \u201cDMT\u201d) for the treatment of stroke in the Netherlands from the Stichting Beoordeling Ethiek Biomedisch Onderzoek (\u201cBEBO\u201d), an independent Medical Research Ethics Committee (\u201cMREC\u201d). The trial will be conducted at the Centre for Human Drug Research (\u201cCHDR\u201d) in Leiden. DMT is a known psychedelic compound that is part of the tryptamine family.<\/p>\n

The Company plans to begin screening shortly and dose the first subject of the study in Q4, 2022.<\/p>\n

The Company\u2019s decision to investigate DMT and move it into human trials for ischemic stroke is based on multiple independent, positive preclinical studies demonstrating that DMT helps mitigate tissue damage and promote neurogenesis as well as structural and functional neural plasticity. These are key factors involved in the brain\u2019s ability to form and reorganize synaptic connections, which are needed for healing following a brain injury. The Company also confirmed in its own murine cortical neuron outgrowth preclinical study, that DMT, in sub-psychedelic doses, increased the growth of cortical neurons by up to 40% compared to control.<\/p>\n

Since there have already been several Phase 1 studies successfully conducted on DMT, the Company is not anticipating any serious adverse events or safety issues arising from its study. The reason that the Company is planning to conduct a Phase 1 study and not directly advance DMT into a Phase 2 study is that it is investigating prolonged intravenous infusion of DMT, for durations which have never been clinically studied. The resulting data generated will help the Company to plan both its Phase 2 acute stroke and rehabilitation studies more effectively.<\/p>\n

\u201cI was drawn to DMT\u2019s endogenous nature and possible role in naturally occurring altered states of consciousness such as dreams and psychosis, as well as being a prototype for other psychedelic drugs in common use,\u201d said Algernon consultant Rick Strassman MD, psychiatrist and psychopharmacologist, and author of the best-selling book DMT: The Spirit Molecule<\/em>. Strassman\u2019s NIH-funded Phase 1 study of DMT, which ran from 1990-1995 at the University of New Mexico, was the first new American clinical research with psychedelic drugs in a generation. The study assessed biological and psychological effects in normal volunteers and demonstrated that studies of psychedelics could be done safely in humans. He continued \u201cOur careful assessment of psychedelic and non-psychedelic doses of DMT established guidelines for studies utilizing its neuroplastogenic effects in stroke, an application I would not have predicted at the time. These more recent findings of DMT\u2019s effects have opened an extraordinarily promising set of potential therapeutic applications for Algernon to explore.\u201d<\/p>\n

Dr. David Nutt, Professor of Neuropsychopharmacology at Imperial College London, also an Algernon consultant, said, \u201cI am pleased to see Algernon moving forward with the CHDR, with whom I have worked in the past and respect greatly,\u201d said. \u201cAlthough the study is in healthy volunteers, the protocol includes study of some markers which may give some early clues about potential benefits in stroke victims.\u201d<\/p>\n

Christopher J. Moreau CEO of Algernon Pharmaceuticals further commented saying, \u201cWe look forward to getting our DMT clinical stroke program started with our Phase 1 study at CHDR in the Netherlands,\u201d said. \u201cThis study will provide important information on dosage and duration of our new DMT IVF formula to help us better plan for our Phase 2 where we plan to test the drug with both acute and recovering stroke patients.\u201d<\/p>\n

Phase 1 DMT Stroke Study Summary<\/strong><\/p>\n

The purpose of the study is to identify the safety, tolerability, and pharmacokinetics of DMT when administered as an intravenous bolus followed by prolonged infusion, for durations which have never been studied clinically. In addition, several pharmacodynamic measures believed to be associated with neuroplasticity, including both measurements of biochemical markers and electroencephalographic readings, will be recorded.<\/p>\n

The first part of the study will use a single-escalating dose design aimed at identifying a safe and tolerable dose that will not produce psychedelic effects, while the second part will test the effects of repeated administrations of this dose. There will be up to 60 healthy volunteers enrolled across the two parts of the study which will include both psychedelic experienced and psychedelic na\u00efve patients.<\/p>\n

About CHDR<\/strong><\/p>\n

Founded in 1986, the CHDR is an independent institute that specializes in cutting-edge early-phase clinical drug research. During the pandemic of 2021 the CHDR completed renovations to greatly increase their clinical capacity while also being responsible for 77 scientific publications.<\/p>\n

CHDR\u2019s custom-built facility is situated in the heart of the Leiden Bio Science Park within Leiden University (LUMC) campus adjacent to the medical school and GMP pharmacy. CHDR\u2019s long-standing partnership with the LUMC facilitates direct access to an extensive knowledge base in Leiden, as well as access to different patient populations for trial recruitment. This partnership as well as the combined expertise of two board certified neurologists and post-doctorate clinical scientists with neuroscientific backgrounds will be valuable assets as Algernon\u2019s DMT program moves forward. In addition, they have performed multiple clinical trials with psychedelic substances, including DMT, and have a suite of rooms specifically created for that purpose.<\/p>\n

The Company had initially retained the CHDR and its affiliated pharmacy at the Leiden University Medical Center in the Netherlands, to develop the IVF that will be used in its Phase 1 DMT study. After working with the CHDR team, it was decided to move forward with an ethics and clinical trial application in Netherlands as well to move Algernon\u2019s DMT stroke research program forward as quickly as possible.<\/p>\n

About DMT<\/strong><\/p>\n

N,N-Dimethyltryptamine, or DMT, is a hallucinogenic tryptamine drug producing effects similar to those of other psychedelics like\u00a0LSD, ketamine, psilocybin and psilocin. DMT occurs naturally in many plant species and animals including humans and has been used in religious ceremonies as a traditional spiritual medicine by indigenous people in the Amazonian basin. DMT can also be synthesised in a laboratory.<\/p>\n

Algernon has filed patents for DMT pamoate and nicotinate (novel salt forms of DMT) in addition to formulation, dosage and method of use claims for ischemic stroke. The Company has also filed claims for combination therapy of DMT and stroke rehabilitation including Constraint Induced Movement Therapy.<\/p>\n

About Algernon Pharmaceuticals Inc.\u00a0<\/strong><\/p>\n

Algernon is a drug re-purposing company that investigates safe, already approved drugs, including naturally occurring compounds, for new disease applications, moving them efficiently and safely into new human trials, developing new formulations and seeking new regulatory approvals in global markets. Algernon specifically investigates compounds that have never been approved in the U.S. or Europe to avoid off label prescription writing.<\/p>\n

CONTACT INFORMATION<\/strong><\/p>\n

Christopher J. Moreau
\nCEO
\nAlgernon Pharmaceuticals Inc.
\n604.398.4175 ext 701<\/p>\n

info@algernonpharmaceuticals.com<\/a>
\ninvestors@algernonpharmaceuticals.com<\/a>
\nwww.algernonpharmaceuticals.com<\/a><\/p>\n

Neither the Canadian Securities Exchange nor its Market Regulator (as that term is defined in the policies of the Canadian Securities Exchange) accepts responsibility for the adequacy or accuracy of this release. <\/em><\/strong><\/p>\n

CAUTIONARY DISCLAIMER STATEMENT: No Securities Exchange has reviewed nor accepts responsibility for the adequacy or accuracy of the content of this news release. This news release contains forward-looking statements relating to product development, licensing, commercialization and regulatory compliance issues and other statements that are not historical facts. Forward-looking statements are often identified by terms such as \u201cwill\u201d, \u201cmay\u201d, \u201cshould\u201d, \u201canticipate\u201d, \u201cexpects\u201d and similar expressions. All statements other than statements of historical fact, included in this release are forward-looking statements that involve risks and uncertainties. There can be no assurance that such statements will prove to be accurate and actual results and future events could differ materially from those anticipated in such statements. Important factors that could cause actual results to differ materially from the Company\u2019s expectations include the failure to satisfy the conditions of the relevant securities exchange(s) and other risks detailed from time to time in the filings made by the Company with securities regulations. The reader is cautioned that assumptions used in the preparation of any forward-looking information may prove to be incorrect. Events or circumstances may cause actual results to differ materially from those predicted, as a result of numerous known and unknown risks, uncertainties, and other factors, many of which are beyond the control of the Company. The reader is cautioned not to place undue reliance on any forward-looking information. Such information, although considered reasonable by management at the time of preparation, may prove to be incorrect and actual results may differ materially from those anticipated. Forward-looking statements contained in this news release are expressly qualified by this cautionary statement. The forward-looking statements contained in this news release are made as of the date of this news release and the Company will update or revise publicly any of the included forward-looking statements as expressly required by applicable law.<\/em><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

VANCOUVER, British Columbia, Sept. 12, 2022 (GLOBE NEWSWIRE) \u2014 Algernon Pharmaceuticals Inc.\u00a0(the \u201cCompany\u201d or \u201cAlgernon\u201d) (CSE: AGN) (FRANKFURT: AGW0) (OTCQB: AGNPF) a clinical stage pharmaceutical development company is pleased to announce that it has received approval to conduct a Phase 1 clinical study of an intravenous formulation (\u201cIVF\u201d) of AP-188 (\u201cN,N-dimethyl tryptamine\u201d or \u201cDMT\u201d) for [\u2026]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[],"yoast_head":"\nAlgernon Pharmaceuticals Receives Approval for Groundbreaking Phase 1 DMT Human Stroke Study - Myanmar News Gazette<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/myanmarnewsgazette.com\/algernon-pharmaceuticals-receives-approval-for-groundbreaking-phase-1-dmt-human-stroke-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Algernon Pharmaceuticals Receives Approval for Groundbreaking Phase 1 DMT Human Stroke Study - 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